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Article

Decreased neuraminidase activity is important for the adaptation of H5N1 influenza virus to human airway epithelium.

Journal of virology - 1 May 2012

Ilyushina Natalia A, Bovin Nicolai V, Webster Robert G

Abstract excerpt

Highly pathogenic avian H5N1 influenza viruses remain a pandemic threat. Antiviral drugs such as neuraminidase (NA) inhibitors will be crucial for disease control in the event of a pandemic. Should drug-resistant H5N1 viruses develop, all defense strategies will be compromised. To determine the likelihood and mechanisms of emergence of NA inhibitor-resistant H5N1 variants in humans, we serially passaged two H5N1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H5N1 Subtype

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Source

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Identifiers

PMID: 22379077
DOI: 10.1128/JVI.06774-11
PMCID: PMC3347354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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