Article
Nitric oxide regulation of cyclic di-GMP synthesis and hydrolysis in Shewanella woodyi.
Biochemistry - 13 Mar 2012
Liu Niu, Xu Yueming, Hossain Sajjad, Huang Nick, Coursolle Dan, Gralnick Jeffrey A, Boon Elizabeth M
Abstract excerpt
Although several reports have documented nitric oxide (NO) regulation of biofilm formation, the molecular basis of this phenomenon is unknown. In many bacteria, an H-NOX (heme-nitric oxide/oxygen-binding) gene is found near a diguanylate cyclase (DGC) gene. H-NOX domains are conserved hemoproteins that are known NO sensors. It is widely recognized that cyclic di-GMP (c-di-GMP) is a ubiquitous bacterial signaling...
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