Article
Vitamin A deficiency associated with urinary retinol binding protein wasting in Dent's disease.
Pediatric nephrology (Berlin, Germany) - 1 Jul 2012
Becker-Cohen Rachel, Rinat Choni, Ben-Shalom Efrat, Feinstein Sofia, Ivgi Heftziba, Frishberg Yaacov
Abstract excerpt
BACKGROUND: Three patients with Dent's disease presented with complaints of impaired night vision or xerophthalmia and were found to have severely decreased serum retinol concentrations. Retinol, bound to its carrier retinol-binding protein (RBP), is filtered at the glomerulus and reabsorbed at the proximal tubule. We hypothesized that urinary loss of retinol-RBP complex is responsible for decreased serum...
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