Article
Use of a molecular diagnostic test in AFB smear positive tuberculosis suspects greatly reduces time to detection of multidrug resistant tuberculosis.
PloS one - 1 Jan 2012
Tukvadze Nestani, Kempker Russell R, Kalandadze Iagor, Kurbatova Ekaterina, Leonard Michael K, Apsindzelashvili Rusudan, Bablishvili Nino, Kipiani Maia, Blumberg Henry M
Abstract excerpt
BACKGROUND: The WHO has recommended the implementation of rapid diagnostic tests to detect and help combat M/XDR tuberculosis (TB). There are limited data on the performance and impact of these tests in field settings. METHODS: The performance of the commercially available Genotype MTBDRplus molecular assay was compared to conventional methods including AFB smear, culture and drug susceptibility testing (DST)...
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