Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women.

doi:10.1158/1055-9965.EPI-11-1168

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Article

Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2012

Limburg Paul J, Limsui David, Vierkant Robert A, Tillmans Lori S, Wang Alice H, Lynch Charles F, Anderson Kristin E, French Amy J, Haile Robert W, Harnack Lisa J, Potter John D, Slager Susan L, Smyrk Thomas C, Thibodeau Stephen N, Cerhan James R

Abstract excerpt

BACKGROUND: Postmenopausal hormone (PMH) therapy represents a controversial colorectal cancer (CRC) preventive intervention. Because colorectal carcinogenesis is a heterogeneous process, we evaluated associations between PMH therapy and incident CRC in relation to KRAS mutation status in a population-based cohort of older women [Iowa Women's Health Study (IWHS)]. METHODS: The IWHS enrolled 41,836 randomly...

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Identifiers

PMID: 22337533
DOI: 10.1158/1055-9965.EPI-11-1168
PMCID: PMC3584684

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KRAS
IMPACT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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