Article
Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys.
American journal of primatology - 1 Sept 2009
Abbott David H, Tarantal Alice F, Dumesic Daniel A
Abstract excerpt
Old World monkeys provide naturally occurring and experimentally induced phenotypes closely resembling the highly prevalent polycystic ovary syndrome (PCOS) in women. In particular, experimentally induced fetal androgen excess in female rhesus monkeys produces a comprehensive adult PCOS-like phenotype that includes both reproductive and metabolic dysfunction found in PCOS women. Such a reliable experimental...
Topics
- Age Factors
- Androgens
- Animals
- Disease Models, Animal
- Female
- Luteinizing Hormone
- Macaca mulatta
- Phenotype
- Polycystic Ovary Syndrome
- Pregnancy
- Prenatal Exposure Delayed Effects