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Article

Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.

Ophthalmology - 1 May 2012

Arita Reiko, Yanagi Yasuo, Honda Norihiko, Maeda Shuji, Maeda Koshi, Kuchiba Aya, Yamaguchi Takuhiro, Yanagihara Yoshitsugu, Suzuki Hiroshi, Amano Shiro

Abstract excerpt

PURPOSE: The primary aim of the present study was to examine the effect of caffeine on tear volume. The secondary aim was to investigate the relation between caffeine-induced changes in tear volume and polymorphisms in ADORA2A and CYP1A2. DESIGN: Double-masked, placebo-controlled, crossover study. PARTICIPANTS: Seventy-eight healthy volunteers were recruited for the study. METHODS: Subjects participated in 2...

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Identifiers

PMID: 22336631
DOI: 10.1016/j.ophtha.2011.11.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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