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Article

Downregulation of transforming growth factor, beta receptor 2 and Notch signaling pathway in human abdominal aortic aneurysm.

Atherosclerosis - 1 Apr 2012

Biros Erik, Walker Philip J, Nataatmadja Maria, West Malcolm, Golledge Jonathan

Abstract excerpt

OBJECTIVE: Mutations in FBN1 and TGFBR2 genes are the main causative mutations identified in Marfan syndrome (MFS). The major vascular complication of MFS is aneurysm formation. Abdominal aortic aneurysm (AAA) is an acquired disease of later life of unknown etiology. The aim of this study was to examine if genetic aberrations in MFS-related genes FBN1 and TGFBR2 are present in patients with AAA. METHODS: We...

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Identifiers

PMID: 22310065
DOI: 10.1016/j.atherosclerosis.2012.01.004

Genes

TGFBR2
FBN1
HEY2
NOTCH3
TAGLN

Provenance

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