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Article

Trypanosoma cruzi discrete typing units in Chagas disease patients from endemic and non-endemic regions of Argentina.

Parasitology - 1 Apr 2012

Cura C I, Lucero R H, Bisio M, Oshiro E, Formichelli L B, Burgos J M, Lejona S, Brusés B L, Hernández D O, Severini G V, Velazquez E, Duffy T, Anchart E, Lattes R, Altcheh J, Freilij H, Diez M, Nagel C, Vigliano C, Favaloro L, Favaloro R R, Merino D E, Sosa-Estani S, Schijman A G

Abstract excerpt

Genetic diversity of Trypanosoma cruzi may play a role in pathogenesis of Chagas disease forms. Natural populations are classified into 6 Discrete Typing Units (DTUs) Tc I-VI with taxonomical status. This study aimed to identify T. cruzi DTUs in bloodstream and tissue samples of Argentinean patients with Chagas disease. PCR-based strategies allowed DTU identification in 256 clinical samples from 239 Argentinean...

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PMID: 22309735
DOI: 10.1017/S0031182011002186

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