Article
Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor.
The European respiratory journal - 1 Aug 2012
Stolk Jan, Stockley Robert A, Stoel Berend C, Cooper Brendan G, Piitulainen Eeva, Seersholm Niels, Chapman Kenneth R, Burdon Jonathan G W, Decramer Marc, Abboud Raja T, Mannes Gregorius P M, Wouters Emiel F, Garrett Jeffrey E, Barros-Tizon Juan C, Russi Erich W, Lomas David A, MacNee William A, Rames Alexis
Abstract excerpt
Palovarotene is an oral γ-selective retinoid agonist. In animal emphysema models, palovarotene reduced inflammation, promoted structural repair and functional improvement. REPAIR (Retinoid treatment of Emphysema in Patients on the α(1)-antitrypsin International Registry), was an investigator-initiated, double-blind, placebo-controlled randomised study to assess the safety and efficacy of 5 mg·day(-1) palovarotene...
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