Article
Reactive oxygen species are involved in ferroportin degradation induced by ceruloplasmin mutant Arg701Trp.
Neurochemistry international - 1 Mar 2012
Persichini Tiziana, De Francesco Giovanni, Capone Caterina, Cutone Antimo, di Patti Maria Carmela Bonaccorsi, Colasanti Marco, Musci Giovanni
Abstract excerpt
The ceruloplasmin mutant R701W, that causes a dramatic phenotype in the young heterozygous patient carrying this mutation, has been shown to have profound effects also in cell culture models. Here we show that Golgi rearrangement and degradation of the iron exporter ferroportin, that follow transfection of cells with this mutant, are accompanied by the massive production of reactive oxygen species (ROS) in the...
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