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Article

Induction of cell proliferation and survival genes by estradiol-repressed microRNAs in breast cancer cells

20 Jan 2012

Abstract excerpt

BACKGROUND: In estrogen responsive MCF-7 cells, estradiol (E₂) binding to ERα leads to transcriptional regulation of genes involved in the control of cell proliferation and survival. MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of gene expression. The aim of this study was to explore whether miRNAs were involved in hormonally regulated expression of estrogen responsive genes. METHODS:...

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PMID: 22260523
DOI: 10.1186/1471-2407-12-29

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