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Article

Angiotensin-converting enzyme insertion/deletion polymorphism is a risk factor for thoracic aortic aneurysm in patients with bicuspid or tricuspid aortic valves.

The Journal of thoracic and cardiovascular surgery - 1 Aug 2012

Foffa Ilenia, Murzi Michele, Mariani Massimiliano, Mazzone Anna Maria, Glauber Mattia, Ait Ali Lamia, Andreassi Maria Grazia

Abstract excerpt

OBJECTIVE: The angiotensin-converting enzyme (ACE) is highly expressed in the aneurysmal vascular wall, in both animal models and human disease. Genetic variations in ACE could be crucial in determining the risk of thoracic aortic aneurysm (TAA). The aim of the present study was to examine the role of ACE insertion/deletion polymorphism on the risk of TAA in patients with bicuspid aortic valves or tricuspid...

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Share to Aortic Aneurysm, Thoracic
Share to Aortic Valve

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Insertional

Share to Peptidyl-Dipeptidase A

Share to Polymorphism, Genetic

Share to Renin-Angiotensin System

Share to Risk Factors

Share to Sequence Deletion

Source

Identifiers

PMID: 22245237
DOI: 10.1016/j.jtcvs.2011.12.038

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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