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Article

Using a cognitive endophenotype to identify risk genes for depression.

Neuroscience letters - 21 Feb 2012

Haeffel Gerald J, Eastman Maria, Grigorenko Elena L

Abstract excerpt

We theorized the cognitive vulnerability factor featured in hopelessness theory [2] to be a novel endophenotype for depression. We investigated two possible genetic contributors to individual differences in cognitive vulnerability (and, in turn, depression): the BDNF gene and the COMT gene. Results showed that individuals (n=95) with the BDNF Val(66) genotype had significantly greater levels of cognitive...

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Source

Identifiers

PMID: 22240101
DOI: 10.1016/j.neulet.2011.12.060

Genes

BDNF
COMT

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