Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VEGF-Mediated STAT3 Activation Inhibits Retinal Vascularization by Down-Regulating Local Erythropoietin Expression

9 Jan 2012

Abstract excerpt

Avascular, hypoxic retina has been postulated to be a source of angiogenic factors that cause aberrant angiogenesis and intravitreal neovascularization (IVNV) in retinopathy of prematurity. Vascular endothelial growth factor (VEGF) is an important factor involved. However, VEGF is also required for normal retinal vascular development, which raises concerns about inhibiting its activity to treat IVNV in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pregnancy and preeclampsia studies
Share to Retinal Diseases and Treatments
Share to Retinopathy of Prematurity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22230249
DOI: 10.1016/j.ajpath.2011.11.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VEGF-Mediated STAT3 Activation Inhibits Retinal Vascularization by Down-Regulating Local Erythropoietin ExpressionPMID 22230249Read ↗

Vascular Endothelial Growth Factor Signaling in Models of Oxygen-Induced Retinopathy: Insights Into Mechanisms of Pathology in Retinopathy of PrematuritySemantic proximity Read ↗

Anti-VEGF Antibody Leads to Later Atypical Intravitreous Neovascularization and Activation of Angiogenic Pathways in a Rat Model of Retinopathy of PrematuritySemantic proximity Read ↗

Short Hairpin RNA-Mediated Knockdown of VEGFA in Müller Cells Reduces Intravitreal Neovascularization in a Rat Model of Retinopathy of PrematuritySemantic proximity Read ↗

RNA-Seq Provides Insights into VEGF-Induced Signaling in Human Retinal Microvascular Endothelial Cells: Implications in Retinopathy of PrematuritySemantic proximity Read ↗

MiR-375 mitigates retinal angiogenesis by depressing the JAK2/STAT3 pathwaySemantic proximity Read ↗

Hypoxia-Induced Retinal Neovascularization in Zebrafish Embryos: A Potential Model of Retinopathy of PrematuritySemantic proximity Read ↗

Müller cell‐derived VEGF is a significant contributor to retinal neovascularizationSemantic proximity Read ↗

SYVN1 Promotes STAT3 Protein Ubiquitination and Exerts Antiangiogenesis Effects in Retinopathy of Prematurity DevelopmentSemantic proximity Read ↗

Roles of Hypoxia Response in Retinal Development and PathophysiologySemantic proximity Read ↗

Abnormal Vascular Phenotypes Associated with the Timing of Interruption of Retinal Vascular Development in Rats.Semantic proximity Read ↗

Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and PhotoreceptorsSemantic proximity Read ↗

Update on Anti-Vascular Endothelial Growth Factor Safety for Retinopathy of PrematuritySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.