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Article

Phase I study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2012

Davies Michael A, Fox Patricia S, Papadopoulos Nicholas E, Bedikian Agop Y, Hwu Wen-Jen, Lazar Alexander J, Prieto Victor G, Culotta Kirk S, Madden Timothy L, Xu Quanyun, Huang Sha, Deng Wanleng, Ng Chaan S, Gupta Sanjay, Liu Wenbin, Dancey Janet E, Wright John J, Bassett Roland L, Hwu Patrick, Kim Kevin B

Abstract excerpt

PURPOSE: This phase I clinical trial was conducted to determine the safety, efficacy, and molecular effects of sorafenib with temsirolimus in patients with advanced melanoma. PATIENTS AND METHODS: Patients with stage IV or unresectable or recurrent stage III melanoma and Eastern Cooperative Oncol...

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Identifiers

PMID: 22223528
DOI: 10.1158/1078-0432.CCR-11-2436
PMCID: PMC3906678

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22223528-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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