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Article

A vaccine candidate for eastern equine encephalitis virus based on IRES-mediated attenuation.

Vaccine - 8 Feb 2012

Pandya Jyotsna, Gorchakov Rodion, Wang Eryu, Leal Grace, Weaver Scott C

Abstract excerpt

To develop an effective vaccine against eastern equine encephalitis (EEE), we engineered a recombinant EEE virus (EEEV) that was attenuated and capable of replicating only in vertebrate cells, an important safety feature for live vaccines against mosquito-borne viruses. The subgenomic promoter was inactivated with 13 synonymous mutations and expression of the EEEV structural proteins was placed under the control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22222869
DOI: 10.1016/j.vaccine.2011.12.121
PMCID: PMC3283035

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