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Article

Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.

Clinical immunology (Orlando, Fla.) - 1 Mar 2012

Moise Leonard, Song Chang, Martin William D, Tassone Ryan, De Groot Anne S, Scott David W

Abstract excerpt

T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues. Here, we used immunoinformatic tools to identify C2 domain HLA DR epitopes and predict site-specific...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22222093
DOI: 10.1016/j.clim.2011.11.010
PMCID: PMC3288193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.PMID 22222093Read ↗

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