Article
Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle.
Animal genetics - 1 Feb 2012
Berkowicz E W, Magee D A, Berry D P, Sikora K M, Howard D J, Mullen M P, Evans R D, Spillane C, MacHugh D E
Abstract excerpt
The regulation of the bioavailability of insulin-like growth factors (IGFs) is critical for normal mammalian growth and development. The imprinted insulin-like growth factor 2 receptor gene (IGF2R) encodes a transmembrane protein receptor that acts to sequester and degrade excess circulating insulin-like growth factor 2 (IGF-II) - a potent foetal mitogen - and is considered an important inhibitor of growth....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.