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Article

TFAP2E-DKK4 and chemoresistance in colorectal cancer.

The New England journal of medicine - 5 Jan 2012

Ebert Matthias P A, Tänzer Marc, Balluff Benjamin, Burgermeister Elke, Kretzschmar Antje Karen, Hughes David J, Tetzner Reimo, Lofton-Day Catherine, Rosenberg Robert, Reinacher-Schick Anke C, Schulmann Karsten, Tannapfel Andrea, Hofheinz Ralf, Röcken Christoph, Keller Gisela, Langer Rupert, Specht Katja, Porschen Rainer, Stöhlmacher-Williams Jan, Schuster Tibor, Ströbel Philipp, Schmid Roland M

Abstract excerpt

BACKGROUND: Chemotherapy for advanced colorectal cancer leads to improved survival; however, predictors of response to systemic treatment are not available. Genomic and epigenetic alterations of the gene encoding transcription factor AP-2 epsilon (TFAP2E) are common in human cancers. The gene encoding dickkopf homolog 4 protein (DKK4) is a potential downstream target of TFAP2E and has been implicated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22216841
DOI: 10.1056/NEJMoa1009473

Genes

DKK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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