Article
Polymorphisms in transcobalamin II gene is associated with coronary artery disease in Indian population.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Mar 2012
Garg Gaurav, Kumar Jitender, Tanwar Vinay Singh, Basak Trayambak, Seth Sandeep, Karthikeyan Ganesan, Sengupta Shantanu
Abstract excerpt
Transcobalamin (TCII) is a key enzyme involved in intracellular transport of vitamin B12. We had earlier shown that vitamin B12 levels are associated with Coronary Artery Disease (CAD). Herein, we evaluated the association of four nonsynonymous single nucleotide polymorphisms (SNPs) of TCII gene with CAD in 1398 individuals (589 CAD cases and 809 controls). Using logistic regression, we found that three SNPs...
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