Article
Transforming growth factor-β1 involved in urotensin II-induced phenotypic differentiation of adventitial fibroblasts from rat aorta.
Chinese medical journal - 1 Dec 2010
Zhang Yong-Gang, Hu Yan-Chao, Mao Yan-Yan, Wei Rui-Hong, Bao Shi-Lin, Wu Li-Biao, Kuang Ze-Jian
Abstract excerpt
BACKGROUND: Urotensin II (UII) is a new vasoconstrictive peptide that may activate the adventitial fibroblasts. Transforming growth factor-β1 (TGF-β1) is an important factor that could induce the phenotypical transdifferentiation of adventitial fibroblasts. This study aimed to explore whether TGF-β1 is involved in UII-induced phenotypic differentiation of adventitial fibroblasts from rat aorta. METHODS:...
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