Article
From genes to phenotypes - evaluation of two methods for the SNP analysis in archaeological remains: pyrosequencing and competitive allele specific PCR (KASPar).
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft - 20 Jan 2012
Pruvost Melanie, Reissmann Monika, Benecke Norbert, Ludwig Arne
Abstract excerpt
The amplification length of the DNA fragments is one major limitation of most paleogenetic analyses. Routinely, only fragments below 200 bp can be amplified, significantly reducing the content of genetic information. Although overlapping PCR strategies and next generation sequencing techniques have strongly improved data mining recently, these methods are still expensive and time consuming. In contrast, SNP...
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