Synthetic lethality of the lytE cwlO genotype in Bacillus subtilis is caused by lack of D,L-endopeptidase activity at the lateral cell wall.

doi:10.1128/JB.05569-11

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Article

Synthetic lethality of the lytE cwlO genotype in Bacillus subtilis is caused by lack of D,L-endopeptidase activity at the lateral cell wall.

Journal of bacteriology - 1 Feb 2012

Hashimoto Masayuki, Ooiwa Seika, Sekiguchi Junichi

Abstract excerpt

Bacterial peptidoglycan acts as an exoskeleton to protect the bacterial cell. Although peptidoglycan biosynthesis by penicillin-binding proteins is well studied, few studies have described peptidoglycan disassembly, which is necessary for a dynamic structure that allows cell growth. In Bacillus subtilis, more than 35 genes encoding cell wall lytic enzymes have been identified; however, only two D,L-endopeptidases...

Topics

Bacillus subtilis
Bacterial Proteins
Bacteriolysis
Cell Wall
Endopeptidases
Genes, Bacterial
Genotype
N-Acetylmuramoyl-L-alanine Amidase
Peptidoglycan
Point Mutation

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Identifiers

PMID: 22139507
DOI: 10.1128/JB.05569-11
PMCID: PMC3272963

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