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Article

Improved Coiled-Coil Design Enhances Interaction with Bcr-Abl and Induces Apoptosis

3 Dec 2011

Abstract excerpt

The oncoprotein Bcr-Abl drives aberrant downstream activity through trans-autophosphorylation of homo-oligomers in chronic myelogenous leukemia (CML).(1, 2) The formation of Bcr-Abl oligomers is achieved through the coiled-coil domain at the N-terminus of Bcr.(3, 4) We have previously reported a modified version of this coiled-coil domain, CCmut2, which exhibits disruption of Bcr-Abl oligomeric complexes and...

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PMID: 22136227
DOI: 10.1021/mp200461s

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