Article
One virus, one lesion--individual components of CIN lesions contain a specific HPV type.
The Journal of pathology - 1 May 2012
Quint Wim, Jenkins David, Molijn Anco, Struijk Linda, van de Sandt Miekel, Doorbar John, Mols Johann, Van Hoof Christine, Hardt Karin, Struyf Frank, Colau Brigitte
Abstract excerpt
In 20-40% of cervical intra-epithelial neoplasia (CIN) and in 4-8% of cervical carcinoma tissue specimens, multiple HPV genotypes have been detected. Whole tissue section (WTS) PCR does not determine how the individual types relate causally to complex and multiple CIN. Our objective was to determine whether laser capture micro-dissection (LCM) with HPV PCR genotyping (LCM-PCR) could accurately recover...
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