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Article

Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study.

PLoS computational biology - 1 Nov 2011

Song Zhuo, Cao Yang, Samuels David C

Abstract excerpt

The activity of polymerase γ is complicated, involving both correct and incorrect DNA polymerization events, exonuclease activity, and the disassociation of the polymerase:DNA complex. Pausing of pol-γ might increase the chance of deletion and depletion of mitochondrial DNA. We have developed a stochastic simulation of pol-γ that models its activities on the level of individual nucleotides for the replication of...

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Identifiers

PMID: 22125488
DOI: 10.1371/journal.pcbi.1002287
PMCID: PMC3219627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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