Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression

Abstract excerpt

BACKGROUND: Glioblastoma multiforme (GBM) is the most common, aggressive and malignant primary tumor of the brain and is associated with one of the worst 5-year survival rates among all human cancers. Identification of molecular interactions that associate with disease progression may be key in finding novel treatments. METHODS: Using five independent molecular and clinical datasets with a set of computational...

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