Article
Functions of intronic nucleotide variants in the gene encoding pleckstrin homology like domain beta 2 (PHLDB2) on susceptibility to vascular dementia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Apr 2013
Eom Sangmi, Lee Chaeyoung
Abstract excerpt
OBJECTIVES: A genome-wide association study (GWAS) failed to detect any genetic associations with susceptibility to vascular dementia (VaD) by the Bonferroni multiple test. This study aimed to discover false negative associations from the GWAS. METHODS: We selected a candidate gene in which multiple associations were identified with its single nucleotide polymorphisms (SNPs). Genetic associations were intensively...
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