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Article

Maternal microchimerism in Hirschsprung's disease.

American journal of perinatology - 1 Feb 2012

Kiefer Autumn S, Lang Tara R, Hein Molly S, McNallan Kelly T, Moir Christopher R, Reed Ann M

Abstract excerpt

Hirschsprung's disease (HD) presents with severe constipation due to absent ganglion cells in the distal rectum. We sought to determine whether maternal chimeric cells are present in aganglionic bowel. We hypothesize that chimeric cells are part of the unfavorable microenvironment that leads to the destruction of enteric neurons in HD. Intestinal biopsies and resections from seven male patients with HD were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22105432
DOI: 10.1055/s-0031-1295645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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