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Article

The progranulin (GRN) Cys157LysfsX97 mutation is associated with nonfluent variant of primary progressive aphasia clinical phenotype.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Caso Francesca, Villa Chiara, Fenoglio Chiara, Santangelo Roberto, Agosta Federica, Coppi Elisabetta, Falautano Monica, Comi Giancarlo, Filippi Massimo, Scarpini Elio, Magnani Giuseppe, Galimberti Daniela

Abstract excerpt

The progranulin gene (GRN) g.10325_10331delCTGCTGT (relative to nt1 in NG_007886.1), alias Cys157LysfsX97, has been so far reported only once in a patient with frontotemporal dementia. Here, we describe a 63-year old patient carrying the same mutation, presenting with a 3-year history of language disorder, and diagnosed clinically with nonfluent variant of primary progressive aphasia according to current...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22072213
DOI: 10.3233/JAD-2011-111544

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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