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Article

miR-1/133a and miR-206/133b clusters overcome HGF induced gefitinib resistance in non-small cell lung cancers with EGFR sensitive mutations.

Journal of drug targeting - 1 Dec 2021

Jiao Demin, Jiang Chunyan, Zhu Linzhi, Zheng Jie, Liu Xibang, Liu Xiang, Chen Jun, Tang Xiali, Chen Qingyong

Abstract excerpt

It has been reported that clustered miRNAs can be transcribed coordinately and exhibit similar functions by regulating the same targets. miR-1/133a and miR-206/133b are well-characterized miRNA clusters. However, the effect of these clusters on EGFR-TKI resistance is not clear. In this study, we demonstrated that lentivirus-mediated HGF overexpression was able to induce gefitinib resistance in non-small cell lung...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33955799
DOI: 10.1080/1061186X.2021.1927054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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