Article
Sex differences in reproductive fitness contribute to preferential maternal transmission of 22q11.2 deletions.
Journal of medical genetics - 1 Dec 2011
Costain Gregory, Chow Eva W C, Silversides Candice K, Bassett Anne S
Abstract excerpt
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion syndrome in humans. In a minority of patients, the underlying 22q11.2 deletion is found to have been inherited, usually from an affected mother. Serious neuropsychiatric conditions that are commonly associated features of 22q11.2DS could disproportionately affect reproductive success in males. METHODS: This study compared standard...
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