Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone Deacetylase 8 Is Required for Centrosome Cohesion and Influenza A Virus Entry

27 Oct 2011

Abstract excerpt

Influenza A virus (IAV) enters host cells by endocytosis followed by acid-activated penetration from late endosomes (LEs). Using siRNA silencing, we found that histone deacetylase 8 (HDAC8), a cytoplasmic enzyme, efficiently promoted productive entry of IAV into tissue culture cells, whereas HDAC1 suppressed it. HDAC8 enhanced endocytosis, acidification, and penetration of the incoming virus. In contrast, HDAC1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine and Purinergic Signaling
Share to HIV Research and Treatment
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22046129
DOI: 10.1371/journal.ppat.1002316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone Deacetylase 8 Is Required for Centrosome Cohesion and Influenza A Virus EntryPMID 22046129Read ↗

Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 proteinSemantic proximity Read ↗

Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entrySemantic proximity Read ↗

ATG9A regulates the dissociation of recycling endosomes from microtubules to form liquid influenza A virus inclusionsSemantic proximity Read ↗

Importin-7-dependent nuclear translocation of the Flavivirus core protein is required for infectious virus productionSemantic proximity Read ↗

Entry of influenza A virus: host factors and antiviral targetsSemantic proximity Read ↗

Histone deacetylase 6 inhibition enhances oncolytic viral replication in gliomaSemantic proximity Read ↗

Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated α-Tubulin Enhances Viral ReplicationSemantic proximity Read ↗

Nucleozin Targets Cytoplasmic Trafficking of Viral Ribonucleoprotein-Rab11 Complexes in Influenza A Virus InfectionSemantic proximity Read ↗

HDAC1 and HDAC2 Are Involved in Influenza A Virus-Induced Nuclear Translocation of Ectopically Expressed STAT3-GFPSemantic proximity Read ↗

Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathwaysSemantic proximity Read ↗

Influenza A virus-induced host caspase and viral PA-X antagonize the antiviral host factor, histone deacetylase 4Semantic proximity Read ↗

siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.