Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of pathogenic human MSH2 missense mutations using yeast as a model system: a laboratory course in molecular biology.

Cell biology education - 1 Jan 2004

Gammie Alison E, Erdeniz Naz

Abstract excerpt

This work describes the project for an advanced undergraduate laboratory course in cell and molecular biology. One objective of the course is to teach students a variety of cellular and molecular techniques while conducting original research. A second objective is to provide instruction in science writing and data presentation by requiring comprehensive laboratory reports modeled on the primary literature. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mismatch Repair
Share to DNA, Recombinant
Share to DNA Restriction Enzymes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to Laboratories

Share to Molecular Biology

Share to MutS Homolog 2 Protein

Share to Oligonucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 22039344
DOI: 10.1187/cbe.03-08-0006
PMCID: PMC3203682

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of pathogenic human MSH2 missense mutations using yeast as a model system: a laboratory course in molecular biology.PMID 22039344Read ↗

Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae.Semantic proximity Read ↗

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Semantic proximity Read ↗

Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domainSemantic proximity Read ↗

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.Semantic proximity Read ↗

Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification.Semantic proximity Read ↗

MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system.Semantic proximity Read ↗

Functional interrogation of Lynch syndrome‐associated MSH2 missense variants via CRISPR‐Cas9 gene editing in human embryonic stem cellsSemantic proximity Read ↗

Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiaeSemantic proximity Read ↗

Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeast.Semantic proximity Read ↗

Functional analysis of HNPCC-related missense mutations in MSH2.Semantic proximity Read ↗

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function.Semantic proximity Read ↗

Saccharomyces cerevisiae pms2 mutations are alleles of MLH1, and pms2-2 corresponds to a hereditary nonpolyposis colorectal carcinoma-causing missense mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.