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Gnarled-Trunk Evolutionary Model of Influenza A Virus Hemagglutinin

10 Oct 2011

Abstract excerpt

Human influenza A viruses undergo antigenic changes with gradual accumulation of amino acid substitutions on the hemagglutinin (HA) molecule. A strong antigenic mismatch between vaccine and epidemic strains often requires the replacement of influenza vaccines worldwide. To establish a practical model enabling us to predict the future direction of the influenza virus evolution, relative distances of amino acid...

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PMID: 22028800
DOI: 10.1371/journal.pone.0025953

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