Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The relative contribution of environmental and genetic factors to phenotypic variation in familial Mediterranean fever (FMF).

Gene - 10 Jan 2012

Ben-Zvi Ilan, Brandt Benny, Berkun Yackov, Lidar Merav, Livneh Avi

Abstract excerpt

INTRODUCTION: Familial Mediterranean fever (FMF) is an autosomal recessive disease, caused by mutations in the FMF gene MEFV (MEditerranean FeVer). It has a large phenotypic diversity even in patients with similar genotypes. Despite evidence that environmental factors (EFs) and genetic factors, including MEFV mutations (such as M694V, E148Q) and background modifier genes (MGs), affect the clinical manifestations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Environment

Share to Familial Mediterranean Fever

Share to MEFV gene

Share to Phenotype

Source

Identifiers

PMID: 22019429
DOI: 10.1016/j.gene.2011.10.005

Genes

MEFV

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

The relative contribution of environmental and genetic factors to phenotypic variation in familial Mediterranean fever (FMF).PMID 22019429Read ↗

Population genetics of familial Mediterranean fever: a review.Semantic proximity Read ↗

The contribution of genotypes at the MICA gene triplet repeat polymorphisms and MEFV mutations to amyloidosis and course of the disease in the patients with familial Mediterranean fever.Semantic proximity Read ↗

Intrafamilial segregation analysis of the p.E148Q MEFV allele in familial Mediterranean fever.Semantic proximity Read ↗

Familial Mediterranean fever: the segregation of four different mutations in 13 individuals from one inbred family: genotype-phenotype correlation and intrafamilial variability.Semantic proximity Read ↗

Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever.Semantic proximity Read ↗

The MICA region determines the first modifier locus in familial Mediterranean fever.Semantic proximity Read ↗

Does breast-feeding affect severity of familial Mediterranean fever?Semantic proximity Read ↗

Results from a multicentre international registry of familial Mediterranean fever: impact of environment on the expression of a monogenic disease in children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.