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Article

Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors.

ACS chemical biology - 20 Jan 2012

Nguyen Thu N T, Saleem Rahman S Z, Luderer Micah J, Hovde Stacy, Henry R William, Tepe Jetze J

Abstract excerpt

DNA damage induced by ionizing radiation activates the ataxia telangiectasia mutated pathway, resulting in apoptosis or DNA repair. The serine/threonine checkpoint kinase (Chk2) is an important transducer of this DNA damage signaling pathway and mediates the ultimate fate of the cell. Chk2 is an advantageous target for the development of adjuvant drugs for cancer therapy, because inhibition of Chk2 allows normal...

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PMID: 22004065
DOI: 10.1021/cb200320c

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ATM

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