Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A therapeutic trial of pro‐methylation dietary supplements in Angelman syndrome

14 Oct 2011

Abstract excerpt

Angelman syndrome (AS) is due to deficient ubiquitin protein ligase 3a, the gene for which (UBE3A) maps to chromosome 15q11-q13 and is imprinted such that only the maternally inherited gene is expressed. The paternally inherited UBE3A gene is silenced, a process mediated by an antisense transcript. We conducted a trial using methylation-promoting dietary supplements (betaine, metafolin, creatine, and vitamin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22002941
DOI: 10.1002/ajmg.a.34297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A therapeutic trial of pro‐methylation dietary supplements in Angelman syndromePMID 22002941Read ↗

Double-blind therapeutic trial in Angelman syndrome using betaine and folic acid.Semantic proximity Read ↗

Therapies in preclinical and clinical development for Angelman syndromeSemantic proximity Read ↗

Emerging Therapies and challenges for individuals with Angelman syndrome.Semantic proximity Read ↗

Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman SyndromeSemantic proximity Read ↗

Dietary Intake of Octanoic Acid Restores UBE3A Expression and Improves the Behavioral Phenotypes in a Mouse Model of Angelman SyndromeSemantic proximity Read ↗

UBE3A reinstatement as a disease‐modifying therapy for Angelman syndromeSemantic proximity Read ↗

Towards a therapy for Angelman syndrome by targeting a long non-coding RNA.Semantic proximity Read ↗

Sleep disturbance in Angelman syndrome patientsSemantic proximity Read ↗

Prenatal treatment path for angelman syndrome and other neurodevelopmental disordersSemantic proximity Read ↗

The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trialSemantic proximity Read ↗

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman SyndromeSemantic proximity Read ↗

Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.