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Article

Reporter phage and breath tests: emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy.

The Journal of infectious diseases - 15 Nov 2011

Jain Paras, Thaler David S, Maiga Mamoudou, Timmins Graham S, Bishai William R, Hatfull Graham F, Larsen Michelle H, Jacobs William R

Abstract excerpt

The rapid and accurate diagnosis of active tuberculosis (TB) and its drug susceptibility remain a challenge. Phenotypic assays allow determination of antibiotic susceptibilities even if sequence data are not available or informative. We review 2 emerging diagnostic approaches, reporter phage and breath tests, both of which assay mycobacterial metabolism. The reporter phage signal, Green fluorescent protein (GFP)...

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Identifiers

PMID: 21996696
DOI: 10.1093/infdis/jir454
PMCID: PMC3247800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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