Involvement of mycobacterium avium subspecies paratuberculosis in TNF-α production from macrophage: Possible link between MAP and immune response in Crohnʼs disease

Abstract excerpt

To the Editor: Crohn's disease (CD) is a chronic disease characterized by recurrent and severe inflammation of the gastrointestinal tract. Despite the unknown etiology, it is considered that chronic activation of the innate and adaptive mucosal immune systems in a genetically susceptible host results in the development of CD and that enteric microflora play a central role in initiation and maintenance of disease....

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