Article
Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines
6 Oct 2011
Abstract excerpt
Temozolomide (TMZ) is the standard chemotherapeutic agent for human malignant glioma, but intrinsic or acquired chemoresistance represents a major obstacle to successful treatment of this highly lethal group of tumours. Obtaining better understanding of the molecular mechanisms underlying TMZ resistance in malignant glioma is important for the development of better treatment strategies. We have successfully...
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