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Article

Novel stromal biomarkers in human breast cancer tissues provide evidence for the more malignant phenotype of estrogen receptor-negative tumors.

Journal of biomedicine & biotechnology - 1 Jan 2011

Khamis Zahraa I, Sahab Ziad J, Byers Stephen W, Sang Qing-Xiang Amy

Abstract excerpt

Research efforts were focused on genetic alterations in epithelial cancer cells. Epithelial-stromal interactions play a crucial role in cancer initiation, progression, invasion, angiogenesis, and metastasis; however, the active role of stroma in human breast tumorigenesis in relation to estrogen receptor (ER) status of epithelial cells has not been explored. Using proteomics and biochemical approaches, we...

Topics

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Chromatography, Liquid
Electrophoresis, Gel, Two-Dimensional
Endothelial Cells
Leukocytes
Myofibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell, alpha-beta

Receptors, Estrogen

Tandem Mass Spectrometry

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Open in PubMed Open full text

Identifiers

PMID: 21976967
DOI: 10.1155/2011/723650
PMCID: PMC3185288

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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