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A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol.

Bioorganic & medicinal chemistry letters - 15 Nov 2011

Fröhlich Richard F G, Fantur Katrin, Furneaux Richard H, Paschke Eduard, Stütz Arnold E, Wicki Jacqueline, Withers Stephen G, Wrodnigg Tanja M

Abstract excerpt

N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol, a strong competitive inhibitor of β-galactosidase, enhances residual β-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant β-gal as well as aberrant GM1 gangliosides by live cell imaging.

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Identifiers

PMID: 21974950
DOI: 10.1016/j.bmcl.2011.09.012

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