Article
Analysis of potential genomic confounding in genetic association studies and an online genomic confounding browser (GCB).
Annals of human genetics - 1 Nov 2011
Raistrick Christopher A, Alharbi Khalid K, Day Ian N M, Gaunt Tom R
Abstract excerpt
Genome-wide association studies have transformed genetic studies of disease susceptibility, identifying many variants that may tag functional polymorphism nearby. Variants are often ascribed to a physically close gene exhibiting plausible functionality for a causal pathway. However, more physically remote genes may be at a lesser linkage or linkage disequilibrium (LD) distance from the tested SNP and could...
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