Article
Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2011
Dhillon Preet K, Penney Kathryn L, Schumacher Fredrick, Rider Jennifer R, Sesso Howard D, Pollak Michael, Fiorentino Michelangelo, Finn Stephen, Loda Massimo, Rifai Nader, Mucci Lorelei A, Giovannucci Edward, Stampfer Meir J, Ma Jing
Abstract excerpt
BACKGROUND: Adiponectin, an insulin-sensitizing adipokine, is inversely associated with adiposity and prostate cancer risk and progression. However, the role of genetic variation in the adiponectin (ADIPOQ) and receptor genes (ADIPOR1/R2) in prostate cancer is largely unknown. METHODS: In a nested case-control study of 1,286 cases and 1,267 controls within the Physicians' Health Study, we evaluated 29 common...
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