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Article

LMNA mutations induce a non-inflammatory fibrosis and a brown fat-like dystrophy of enlarged cervical adipose tissue.

The American journal of pathology - 1 Nov 2011

Béréziat Véronique, Cervera Pascale, Le Dour Caroline, Verpont Marie-Christine, Dumont Sylvie, Vantyghem Marie-Christine, Capeau Jacqueline, Vigouroux Corinne

Abstract excerpt

Some LMNA mutations responsible for insulin-resistant lipodystrophic syndromes are associated with peripheral subcutaneous lipoatrophy and faciocervical fat accumulation. Their pathophysiologic characteristics are unknown. We compared histologic, immunohistologic, ultrastructural, and protein expression features of enlarged cervical subcutaneous adipose tissue (scAT) obtained during plastic surgery from four...

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Source

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Identifiers

PMID: 21945321
DOI: 10.1016/j.ajpath.2011.07.049
PMCID: PMC3204020

Genes

LMNA
UCP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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