Article
Associated risk of XRCC1 and XPD cross talk and life style factors in progression of head and neck cancer in north Indian population.
Mutation research - 3 Jan 2012
Kumar Anil, Pant Mohan Chand, Singh Hirdya Shanker, Khandelwal Shashi
Abstract excerpt
Effective DNA repair machinery ensures maintenance of genomic integrity. Environmental insults, ageing and replication errors necessitate the need for proper DNA repair systems. Any alteration in DNA repair efficacy would play a dominant role in progression of squamous cell carcinoma of head and neck (SCCHN). Genotypes of XRCC1 gene-Arg194Trp, Arg280His, Arg399Gln and XPD Lys751Gln, by PCR-RFLP were studied in...
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