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Article

Genetic suppression demonstrates interaction of TonB protein with outer membrane transport proteins in Escherichia coli.

Journal of bacteriology - 1 Jul 1990

Bell P E, Nau C D, Brown J T, Konisky J, Kadner R J

Abstract excerpt

Energy-coupled reactions of the Escherichia coli outer membrane transport proteins BtuB and Cir require the tonB product. Some point mutations in a region of btuB and cir that is highly conserved in TonB-dependent transport proteins led to loss of TonB-coupled uptake of vitamin B12 and colicin Ia, whereas binding was unaffected. Most other point mutations in this region had no detectable effect on transport...

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Identifiers

PMID: 2193917
DOI: 10.1128/jb.172.7.3826-3829.1990
PMCID: PMC213362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genetic suppression demonstrates interaction of TonB protein with outer membrane transport proteins in Escherichia coli.PMID 2193917Read ↗

Molecular characterization of the Enterobacter aerogenes tonB gene: identification of a novel type of tonB box suppressor mutant.Semantic proximity Read ↗

Regions of Escherichia coli TonB and FepA proteins essential for in vivo physical interactions.Semantic proximity Read ↗

The wild-type allele of tonB in Escherichia coli is dominant over the tonB1 allele, encoding TonBQ160K, which suppresses the btuB451 mutation.Semantic proximity Read ↗

Sequence changes in the ton box region of BtuB affect its transport activities and interaction with TonB protein.Semantic proximity Read ↗

Structure-function analysis of the vitamin B12 receptor of Escherichia coli by means of informational suppression.Semantic proximity Read ↗

Partial suppression of an Escherichia coli TonB transmembrane domain mutation (delta V17) by a missense mutation in ExbB.Semantic proximity Read ↗

Import-defective colicin B derivatives mutated in the TonB box.Semantic proximity Read ↗

TonB and the gram-negative dilemma.Semantic proximity Read ↗

Monomeric TonB and the Ton box are required for the formation of a high-affinity transporter-TonB complex.Semantic proximity Read ↗

Energetics of colicin import revealed by genetic cross-complementation between the Tol and Ton systems.Semantic proximity Read ↗

Performance of standard phenotypic assays for TonB activity, as evaluated by varying the level of functional, wild-type TonB.Semantic proximity Read ↗

Identification of the periplasmic cobalamin-binding protein BtuF of Escherichia coli.Semantic proximity Read ↗

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