Article
The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02_AG HIV-1 subtype.
The Journal of antimicrobial chemotherapy - 1 Dec 2011
Malet Isabelle, Fourati Slim, Charpentier Charlotte, Morand-Joubert Laurence, Armenia Daniele, Wirden Marc, Sayon Sophie, Van Houtte Margriet, Ceccherini-Silberstein Francesca, Brun-Vézinet Françoise, Perno Carlo-Federico, Descamps Diane, Capt André, Calvez Vincent, Marcelin Anne-Geneviève
Abstract excerpt
BACKGROUND: Most of the previous studies that explored the molecular basis of raltegravir resistance were conducted studying the HIV-1 B subtype. It has been shown that the CRF02_AG subtype in relation to its natural integrase (IN) sequence could develop different genetic pathways associated with raltegravir resistance. The aim of this study was to explore resistance pathways preferably used by CRF02_AG viruses...
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